Log_CL in vitro, int (mL/h/mg protein)
08.44_InVitroHCL_HumanMic_AllReactions_a_rank4
QSAR PaDEL-Descriptor model for intrinsic in vitro clearance of heterogeneous chemicals measured in microsome assay.
The in vitro intrinsic clearance represents the liver's ability to transform the substance 
independently of the blood flow and the availability of the substance.
The in vitro intrinsic clearance is defined as the ratio between the maximum speed of the reaction and the Michaelis constant.
Toxtree software has been used to predict the most likely reactions that can occur at Cytochrome P450 enzyme level.
This model can be applied for all the metabolic reactions identified, alcohol oxidation, aliphatic hydroxylation, amine hydroxylation,
aromatic hydroxylation, epoxidation, N-dealkylation, N-oxidation, O-dealkylation and S-oxidation.
