EDUCATION
Graduation in Pure Chemistry (Organic Natural Compounds) cum
laude - 1972, University of Milan.
EMPLOYMENT
-Full
Professor of Environmental Chemistry and Cultural
Heritage, Faculty
of Sciences (Biology, Biotechnology, Natural Sciences
and Environmental Engineer courses) Insubria University-
present (since 2005)
-Associate
Professor of Organic Chemistry 1995 –2005, Faculty of Sciences (Biology,
Biotechnology, Natural Sciences courses) Insubria
University
-Researcher
in Organic Chemistry
1981- 1995 Department of Organic Chemistry, Milano University
(Associate Professor in 1987).
-Research
Contractor in Organic Chemistry 1975-1981 Department of Organic Chemistry,
Milano University
-Fellowshiper (Lincei Nat. Acad. and MIUR) 1972-1975 Department of Organic Chemistry, Milano University
Professional
Qualifications and Associations:
Recent Research interests:
At
the University of Milan PG carried out researches
on the biosynthesis, structural elucidation, synthesis,
and biotransformation of organic natural products
in the Department of Organic and Industrial Chemistry
till 1994. Her present research field in University
of Insubria, where she is leading the QSAR Research
Unit in Environmental Chemistry and Ecotoxicology,
is on QSAR modelling of organic environmental
pollutants. Different classes of organic compounds
(POPs, PBTs, PAHs, Pesticides, EDs, etc.) have
been studied by chemometric/QSAR approaches to
highlight the relationship between molecular structure
and various physico-chemical and analytical properties
or biological activities, such as toxicity, biodegradability,
persistence, mutagenicity, endocrine disruptor
properties, etc.
Recent
applications of these studies deal with tropospheric
oxidations of Volatile Organic Compounds (VOCs),
Persistent Organic Pollutants (POPs) long-range
transport and persistence, pesticide partition
properties, mutagenicity/carcinogenicity of PAHs/PACs,
Bioconcentration Factor (BCF) and Endocrine Disruptors
Chemicals (EDCs) modeling. The main field of interest
is relative to Persistent Bioaccumulative and
Toxic (PBTs) chemicals. An important aspect of
the research is the proposal of methods for the
validation of QSAR models.
Her
group has been involved in two previous EU Projects
(PREDICT and BEAM) on aquatic toxicity and mixture
toxicity. She is actually leader of a Workpackage
in the EU-FP7 Project CADASTER for REACH and in
a PRIN project for PBT and ED modelling also for
REACH. Paola has worked as QSAR expert for the
European Joint Research Centre (Ispra) and was
member of the OECD Task Force of QSAR Experts
for the definition of the OECD principles for
QSAR validation for regulation applicability.
PG has many international collaborations (in EU,
but also in USA, China and India).
Teaching experience and appointments
The
teaching activity is devoted to various courses
related to the environmental pollution by chemicals
for Biology (Environmental Pollution and Ecotoxicology)
and Engineering for Environmental and Work safety
degrees, in particular: Environmental Chemistry
I and II, Risk Assessment, Analytical Chemistry
and Chemometrics, Environmental Legislation and
Certification, in addition to the course of Organic
Chemistry for Biology, Biotechnology and Analysis/Protection
of Natural Resources. Paola Gramatica is Coordinator
of Environmental Pollution and Ecotoxicology courses
for the Degrees in Biology (undergraduate and
graduate).
Address:
QSAR
Research Unit in Environmental Chemistry and Ecotoxicology
Department of Theoretical and Applied Sciences
Insubria
University
Via
J.H. Dunant 3
21100
Varese – Italy
Telephone:
+
39 0332 421573
Fax: +
39 0332 421554
e-mail:
paola.gramatica@uninsubria.it
web :
http://dipbsf.uninsubria.it/qsar/
; http://www.qsar.it
Personal
Information:
Married;
2 sons